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Among various orthotropic xenograft models, we have experience in orthotopic inoculation of tumors into mammary gland, prostate, abdomen, bladder and under the ovarian bursa. Furthermore, expertise in inoculation of the tumors under the kidney capsule is available. Of the orthotopic models provided, the model for castration resistant prostate cancer utilizing the VCaP cells is well validated, including antiandrogen treatments with known superantagonists (Knuuttila et al., Am J Pathol. 184:2163-73, 2014).
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