Profile
Elisa Närvä
Adjunct Professor in Stem Cell Science
Principal Investigator Pluripotency & Cancer Laboratory
ORCID ID: 0000-0003-0517-9436
Description of Research
Representative Publications
Sandelin S., Hakala S., Lehtinen L. & Närvä E. Generation of three isogenic human induced pluripotent stem cell lines from normal neonate skin fibroblasts. Stem Cell Res. Feb:74:103301, 2024
Närvä E. Onko syövän kantasolujen kliininen tunnistaminen vieläkin mahdotonta? Lääketieteellinen aikakausikirja DUODECIM. 139(19):1547-53, 2023
Närvä E., Taskinen ME., Lilla S., Isomursu A., Pietilä M., Weltner J., Isola J., Sihto H., Joensuu H., Zanivan S., Norman J., Ivaska J. MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels. iScience. May 25;25(6):104459, 2022
Taskinen ME*, Närvä E*, Conway JRW, Hinojosa LS, Lilla S, Mai A, De Franceschi N, Elo LL, Grosse R, Zanivan S, Norman JC, Ivaska J. MASTL promotes cell contractility and motility through kinase-independent signaling. J Cell Biol. Jun 1;219(6), 2020
Conway JRW*, Närvä E*, Taskinen ME*, Ivaska J. Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting. Cells. Jul 6;9(7):E1624, 2020
Stubb A.*, Guzmán C.*, Närvä E, Aaron J., Chew T-L., Saari M., Miihkinen M., Jacquemet G., Ivaska J. Superresolution architecture of pluripotency guarding adhesions. Nature Commun. Oct 18;10(1):4756, 2019
Pietilä M*, Sahgal P.*, Peuhu E., Jäntti N., Paatero I., Närvä E., Al-Akhrass H., Lilja J., Georgiadou M., Andersen O., Padzik A., Sihto H., Joensuu H., Blomqvist M., Saarinen I., Boström P., Taimen P. & Ivaska J. SORLA regulates endosomal trafficking and oncogenic fitness of HER2. Nature Commun. May 28;10(1):2340, 2019
Närvä E, Stubb A, Guzmán C, Blomqvist M, Balboa D, Lerche M, Saari M, Otonkoski T, Ivaska J. A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion. Stem Cell Reports (2017) Jul 11;9(1):67-76.
Emani MR*, Närvä E*, Stubb A, Chakroborty D, Viitala M, Rokka A, Rahkonen N, Moulder R, Denessiouk K, Trokovic R, Lund R, Elo LL, Lahesmaa R. The L1TD1 Protein Interactome Reveals the Importance of Post-transcriptional Regulation in Human Pluripotency. Stem Cell Reports (2015) Mar 10;4(3):519-28.
Närvä E.*, Pursiheimo J-P.*, Laiho A., Rahkonen N., Maheswara R. E., Viitala M., Laurila K., Sahla R., Lund R., Lähdesmäki H., Jaakkola P. and Lahesmaa R. Continuous Hypoxic Culturing of Human Embryonic Stem Cells Enhances SSEA-3 and MYC Levels. Plos One (2013). Nov 13;8(11):e78847.
Kong L.*, Aho K-L*, Granberg K.*, Lund R.*, Järvenpää L., Seppälä J., Gokhale P., Leinonen K., Hahne L., Mäkelä J., Laurila K., Pukkila H., Närvä E., Yli-Harja O., Andrews P. W., Nykter M., Lahesmaa R., Roos C. & Autio R. ESTOOLS Data@Hand: human stem cell gene expression resource. Nature Methods (2013), Sep;10(9):814-815.
Lund R.*, Nikula T.*, Rahkonen N., Närvä E., Baker D., Harrison N., Andrews P., Otonkoski T., Lahesmaa R. High-Throughput Karyotyping of Human Pluripotent Stem Cells. Stem Cell Research (2012), Jul 11;9(3):192-195
Lund R.*, Närvä E.* & Lahesmaa R. Genetic and Epigenetic stability of human pluripotent stem cells. Nature Reviews Genetics (2012) Oct;13(10):732-44.
Närvä E., Rahkonen N., Maheswara R. E., Lund R., Pursiheimo J-P., Nästi J., Autio R., Rasool O., Denessiouk K., Lähdesmäki H., Rao A. and Lahesmaa R. RNA Binding Protein L1TD1 Interacts with LIN28 via RNA and Is Required for Human Embryonic Stem Cell Self-renewal and Cancer Cell Proliferation. STEM CELLS (2012) Mar;30(3):452-60
Hussein S. M.*, Batada N. N.*, Vuoristo S., Ching R. W., Autio R., Närvä E., Ng S., Sourour M., Hämäläinen R., Cia Olsson, Lundin K., Mikkola M., Trokovic R., Peitz M., Brüstle O., Bazett-Jones D. P., Alitalo K., Lahesmaa R., Nagy A. & Otonkoski T. Copy number variation and selection during reprogramming to pluripotency. Nature (2011) Mar 3;471(7336):58-62.
Närvä E., Autio R., Rahkonen N., Kong L., Harrison N., Kitsberg D., Borghese L., Itskovitz-Eldor J., Rasool O., Dvorak P., Hovatta O., Otonkoski T., Tuuri T., Cui W., Brüstle O., Baker D., Maltby E., Moore H. D., Benvenisty N., Andrews P. W., Yli-Harja O. & Lahesmaa R.. High-resolution DNA analysis of Human Embryonic Stem Cell lines reveals culture-induced copy number changes and loss of heterozygosity. Nature Biotechnology (2010) Apr;28(4):371-7.