Profile
Description of Research
In this research project the function of myeloid cells in regulation of immune responses is evaluated. This includes chronic inflammations and autoimmunity as well as the role of tumor associated macrophages (TAMs) in maintaining an immunosuppressive status in the tumor microenvironment and promotion of cancer cell migration and invasion. Special emphasis is put on the (exosomal) miRNA communication between different cell populations locally and distally. Further, novel treatment modalities based either on hormone receptor signaling or the pleiotropic effects of bisphosphonate (induced) metabolites are being sought to modulate the function of the myeloid cell population to make it more feasible for the patient.
Representative Publications
Petruk N, Sousa S, Croset M, Polari L, Zlatev H, Selander K, Mönkkönen J, Clézardin P, Määttä J. Liposome-encapsulated zoledronate increases inflammatory macrophage population in TNBC tumours. Eur J Pharm Sci. 2023 Nov 1;190:106571
Hagberg Thulin M, Määttä J, Linder A, Sterbova S, Ohlsson C, JDamber J-E, Widmark A, Persson E. (2021) Inhibition of STAT3 prevents bone metastatic progression of prostate cancer in vivo. The Prostate, 10.1002/pros.24125
Polari L, Anttila S, Helenius T, Wiklund A, Linnanen T, Toivola DM, Määttä J (2019) Novel Selective Estrogen Receptor Modulator Ameliorates Murine Colitis. International Journal of Molecular Sciences, Jun 20;20(12).
Polari L, Wiklund A, Sousa S, Kangas L, Linnanen T, Härkönen P, Määttä J. (2018) SERMs promote anti-inflammatory signaling and phenotype of CD14+ cells. Inflammation, 41, 1157-1171
Bendre A, Moritz N, Väänänen V, Määttä JA (2018) Dicer1 ablation in osterix positive bone forming cells affects cortical bone homeostasis. Bone, 106, 139-147
Bendre A, Büki KG, Määttä JA. (2017) Fam3c modulates osteogenic differentiation by down-regulating Runx2, Differentiation, 93, 50-57
Sousa S, Brion R, Lintunen M, Kronqvist P, Sandholm J, Mönkkönen J, Joensuu H, Heymann D, Määttä J. (2015) Human breast cancer cells educate macrophages toward the M2 activation status. Breast Cancer Research, 17:101
Sousa S, Auriola S, Mönkkönen J, Määttä J. (2015) N-BPs skew murine macrophages cultured with soluble factors from breast cancer cells toward M1 phenotype. BMC Cancer, 15:4
Arkko S, Zlatev HP, Mönkkönen H, Räikkönen J, Bendzaïd I, Clézardin P, Mönkkönen J, Määttä JA. (2015) Upregulation of the mevalonate pathway by cholesterol depletion abolishes tolerance to N-bisphosphonate induced Vγ9Vδ2 T cell cytotoxicity in PC-3 prostate cancer cells. Cancer Letters, 357, 279-85
Määttä JA, Büki KG, Gu G, Alanne MH, Vääräniemi J, Liljenbäck H, Poutanen M, Härkönen P, Väänänen K. (2013) Inactivation of Estrogen Receptor Alpha in Bone Forming Cells Induces Bone Loss in Female Mice. Faseb Journal, 27, 478-488
Määttä JA, Nieminen-Pihala V, Büki KG, Elo TD, Silvola T, Poutanen M, Härkönen P, Väänänen K. (2013) Inactivation of the Androgen Receptor in Bone Forming Cells Leads to Trabecular Bone Loss in Adult Female Mice. BoneKEy Reports 2, Article number: 440