Profile
Description of Research
Our main interests are related to investigating cardiovascular functions, i.e. the role of alpha 2-adrenoceptors and hypoxia. Our in vitro methods to test cardiac and vascular functions include isometric micromyography, the Langendorff perfused heart preparation and the Radnoti working heart model. In addition, we are interested in pharmacokinetics of alpha 2-adrenoceptor-related drugs, also receptor subtype-selective ones. including urodynamical sturies in animal models.
Representative publications
Uurasmaa TM, Streng T, Alkio M, Heinonen I, Anttila K. Short-term exercise affects cardiac function ex vivo partially via changes in calcium channel levels, without influencing hypoxia sensitivity J Physiol Biochem. 2021 Nov;77(4):639-651
Anttila K, Farrell AP, Patterson DA, Hinch SG & Eliason EJ (2019). Cardiac SERCA activity in sockeye salmon populations: an adaptive response to migration conditions. Can J Fish Aquat Sci 76:1-5
Anttila K, Mauduit F, Le Floch S, Claireaux G & Nikinmaa M (2017). Influence of crude oil exposure on cardiac function and thermal tolerance of juvenile rainbow trout and European seabass. Environ Sci Poll Res 24:19624-19634
Eliason E & Anttila K (2017). Temperature and the Cardiovascular System. In a book: Fish Physiology. Ed. Gamperl AK, Gillis TE, Farrell AP & Brauner CJ. Springer. pp. 235-297
Streng T, Santti R, Andersson KE. Voiding effects mediated by α2-adrenoceptors in the anaesthetized male rat. BJU Int. 2010 Nov;106(10):1546-9