TCDM provides expertise and research facilities to support the analysis of reproductive phenotypes in your mouse models, such as sexual maturation, function of reproductive organs, infertility, subfertility, reproductive tract morphology, structure and function of the reproductive tract
Facilities and services
- Analysis of reproductive performance
- In vitro fertilization (IVF) and other functional tests
- Morphological analyses
- Hormone analyses
Analysis of the reproductive phenotype in female and male mice include:
- Birth weight and weight gain (growth curve)
- Anogenital distance in newborns
- Age of vaginal opening and appearance of nipples
- Estrus cycle, induction of ovulation
- Testicular descent / cryptorchidism
- Mating (mating plugs, pregnancies, litter size and sex ratio)
- Success of lactation and survival of offspring (weight gain of pups during lactation)
- Weight and macroscopic anatomy of reproductive organs
- Sperm structure and motility (CASA analysis), in vitro fertilization
- Number of spermatozoa in epididymis and uterus after mating
- Histology of male and female reproductive organs (also whole-mounts)
- Serum hormone levels (testosterone, estradiol, progesterone, prolactin, LH, FSH)
- Expression of key genes for reproductive functions